Details

Autor(en) / Beteiligte

• Elion Assiana, Darrel Ornelle
• Abdul, Jabar Babatunde Pacôme Achimi
• Linguissi, Laure Stella Ghoma
• Epola, Micheska
• Vouvoungui, Jeannhey Christevy
• Mabiala, Albert
• Biyogho, Christopher Mebiame
• Ronald Edoa, Jean
• Adegbite, Bayodé Roméo
• Adegnika, Ayola Akim
• Elton, Linzy
• Canseco, Julio Ortiz
• McHugh, Timothy D
• Ahombo, Gabriel
• Ntoumi, Francine

Titel

Epidemiological profile of multidrug-resistant and extensively drug-resistant Mycobacterium Tubrculosis among Congolese patients

Ist Teil von

• Annals of clinical microbiology and antimicrobials, 2021-12, Vol.20 (1), p.84-84

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• There is paucity of data on the prevalence and distribution of multidrug- Resistant-Tuberculosis (MDR-TB) in the Republic of Congo. Among the challenges resides the implementation of a robust TB resistance diagnostic program using molecular tools. In resource limited settings there is a need to gather data to enable prioritization of actions. The objective of this study was is to implement molecular tools as a best of diagnosing MDR and XDR-TB among presumptive tuberculosis patients referred to reference hospital of Makelekele in Brazzaville, Republic of the Congo. We have conducted a cross-sectional study, including a total of 92 presumptive pulmonary tuberculosis patients and who had never received treatment recruited at the reference hospital of Makelekele from October 2018 to October 2019. The socio-demographic and clinical data were collected as well as sputum samples. Rifampicin resistance was investigated using Xpert (Cepheid) and second-line TB drugs Susceptibility testing were performed by the Brucker HAIN Line Probe Assay (GenoType MTBDRsl VER 2.0 assay) method. From the 92 recruited patients, 57 (62%) were found positive for the Mycobacterium tuberculosis complex. The prevalence of rifampicin-resistant tuberculosis (RR-TB) was 9.8% (9/92) and importantly 2.2% were pre-XDR/XDR. This study showed a high rate of rifampicin resistance and the presence of extensively drug-resistant tuberculosis in the study area in new patients. This study highlights the need for further studies of TB drug resistance in the country.