Details

Autor(en) / Beteiligte

• Wolpe, Noham
• Ingram, James N
• Tsvetanov, Kamen A
• Geerligs, Linda
• Kievit, Rogier A
• Henson, Richard N
• Wolpert, Daniel M
• Rowe, James B

Titel

Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits

Ist Teil von

• Nature communications, 2016-10, Vol.7 (1), p.13034-13034, Article 13034

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The control of voluntary movement changes markedly with age. A critical component of motor control is the integration of sensory information with predictions of the consequences of action, arising from internal models of movement. This leads to sensorimotor attenuation-a reduction in the perceived intensity of sensations from self-generated compared with external actions. Here we show that sensorimotor attenuation occurs in 98% of adults in a population-based cohort (n=325; 18-88 years; the Cambridge Centre for Ageing and Neuroscience). Importantly, attenuation increases with age, in proportion to reduced sensory sensitivity. This effect is associated with differences in the structure and functional connectivity of the pre-supplementary motor area (pre-SMA), assessed with magnetic resonance imaging. The results suggest that ageing alters the balance between the sensorium and predictive models, mediated by the pre-SMA and its connectivity in frontostriatal circuits. This shift may contribute to the motor and cognitive changes observed with age.