Journal of diabetes investigation, 2022-04, Vol.13 (4), p.611-613
2022
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Details
- Autor(en) / Beteiligte
- Titel
- Research following genome‐wide association study focuses on the multifaceted nature of Src kinase‐associated phosphoprotein 2 in type 1 diabetes
- Ist Teil von
- Journal of diabetes investigation, 2022-04, Vol.13 (4), p.611-613
- Ort / Verlag
- Japan: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Rutsch et al. identified a patient with type 1 diabetes having a rare Src kinase‐associated phosphoprotein 2 variant and investigated the details. As a result, they showed that rare Src kinase‐associated phosphoprotein 2 c.475 G>A increases macrophage activity and promotes type 1 diabetes, as well as autoimmune and inflammatory diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2040-1116eISSN: 2040-1124DOI: 10.1111/jdi.13744Titel-ID: cdi_doaj_primary_oai_doaj_org_article_20587d99f278435a9e3b7cce3e23c7ab
- Format
- –
- Schlagworte
- Antigens, Apoptosis, Cell activation, Conformation, Cytokines, Diabetes, Diabetes mellitus (insulin dependent), Diabetes Mellitus, Type 1 - genetics, Fibroblasts, Gene expression, Genetic disorders, Genome-wide association studies, Genome-Wide Association Study, Genomes, Genotype & phenotype, Humans, Inflammatory diseases, Integrins, Kinases, Leukocyte migration, Ligands, Macrophages, Metastases, Monocytes, Mutation, Phenotypes, Phosphoproteins - genetics, Polymorphism, Proteins, Single-nucleotide polymorphism, src-Family Kinases - genetics