International Journal of Molecular Sciences, 2016-01, Vol.17 (1), p.124-124
2016
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- Autor(en) / Beteiligte
- Titel
- Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules
- Ist Teil von
- International Journal of Molecular Sciences, 2016-01, Vol.17 (1), p.124-124
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Adipogenesis is the process by which precursor stem cells differentiate into lipid laden adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene expression program. In mammalian cells, the peroxisome proliferator-activated receptor γ (PPARγ), and the CCAAT/enhancer binding proteins (C/EBPs) such as C/EBPα, β and δ are considered the key early regulators of adipogenesis, while fatty acid binding protein 4 (FABP4), adiponectin, and fatty acid synthase (FAS) are responsible for the formation of mature adipocytes. Excess accumulation of lipids in the adipose tissue leads to obesity, which is associated with cardiovascular diseases, type II diabetes and other pathologies. Thus, investigating adipose tissue development and the underlying molecular mechanisms is vital to develop therapeutic agents capable of curbing the increasing incidence of obesity and related pathologies. In this review, we address the process of adipogenic differentiation, key transcription factors and proteins involved, adipogenic regulators and potential anti-adipogenic bioactive molecules.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms17010124Titel-ID: cdi_doaj_primary_oai_doaj_org_article_1ee66f99cf86424fa7a9b0ef97faa1f3
- Format
- –
- Schlagworte
- Adipocytes, Adipocytes - drug effects, Adipocytes - metabolism, Adipocytes - pathology, adipogenesis, Adipogenesis - drug effects, Adipogenesis - genetics, Adiponectin - genetics, Adiponectin - metabolism, adipose tissue, Adipose Tissue - drug effects, Adipose Tissue - metabolism, Adipose Tissue - pathology, Animals, C/EBPα, CCAAT-Enhancer-Binding Protein-delta - genetics, CCAAT-Enhancer-Binding Protein-delta - metabolism, CCAAT-Enhancer-Binding Proteins - genetics, CCAAT-Enhancer-Binding Proteins - metabolism, Fatty Acid Synthase, Type I - genetics, Fatty Acid Synthase, Type I - metabolism, Fatty Acid-Binding Proteins - genetics, Fatty Acid-Binding Proteins - metabolism, Gene Expression Regulation, Genistein - therapeutic use, Humans, Hydroxycholesterols - therapeutic use, Mice, Molecules, obesity, Obesity - drug therapy, Obesity - genetics, Obesity - metabolism, Obesity - pathology, PPAR gamma - genetics, PPAR gamma - metabolism, PPARγ, Protein Isoforms - genetics, Protein Isoforms - metabolism, Review, Signal Transduction, Stem cells, Stilbenes - therapeutic use