Details

Autor(en) / Beteiligte

• Sebastian, Nikhil T
• Raj, Rohit
• Prasad, Rahul
• Barney, Christian
• Brownstein, Jeremy
• Grecula, John
• Haglund, Karl
• Xu-Welliver, Meng
• Williams, Terence M
• Bazan, Jose G

Titel

Association of Pre- and Posttreatment Neutrophil-Lymphocyte Ratio With Recurrence and Mortality in Locally Advanced Non-Small Cell Lung Cancer

Ist Teil von

• Frontiers in oncology, 2020-11, Vol.10, p.598873-598873

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Neutrophil-lymphocyte ratio (NLR) has been associated with mortality in non-small cell lung cancer (NSCLC), but its association with recurrence in locally advanced NSCLC (LA-NSCLC), specifically, is less established. We hypothesized pre- and posttreatment NLR would be associated with recurrence and mortality. We studied the association of pretreatment NLR (pre-NLR) and posttreatment NLR at 1 (post-NLR ) and 3 months (post-NLR ) with outcomes in patients with LA-NSCLC treated with chemoradiation. Pre-NLR was dichotomized by 5, an cutoff previously shown to be prognostic in LA-NSCLC. Post-NLR and post-NLR were dichotomized by their medians. We identified 135 patients treated with chemoradiation for LA-NSCLC between 2007 and 2016. Median follow-up for living patients was 61.1 months. On multivariable analysis, pre-NLR ≥ 5 was associated with worse overall survival (HR = 1.82; 95% CI 1.15 - 2.88; p = 0.011), but not with any recurrence, locoregional recurrence, or distant recurrence. Post-NLR ≥ 6.3 was not associated with recurrence or survival. Post-NLR ≥ 6.6 was associated with worse overall survival (HR = 3.27; 95% CI 2.01- 5.31; p < 0.001), any recurrence (HR = 2.50; 95% CI 1.53 - 4.08; p < 0.001), locoregional recurrence (HR = 2.50; 95% CI 1.40 - 4.46; p = 0.002), and distant recurrence (HR = 2.53; 95% CI 1.49 - 4.30; p < 0.001). Pretreatment NLR is associated with worse overall survival and posttreatment NLR is associated with worse survival and recurrence. These findings should be validated independently and prospectively studied.