Details

Autor(en) / Beteiligte

• Araújo, Helena Varela de
• Correia, Rodolfo Patussi
• Bento, Laiz Cameirão
• Vaz, Andressa da Costa
• Sousa, Flávia Arandas de
• Alexandre, Anderson Marega
• Schimidell, Daniela
• Pedro, Eduardo de Carvalho
• Ioshida, Márcia Regina
• Barroso, Rodrigo de Souza
• Bacal, Nydia Strachman

Titel

Myelodysplastic syndrome: validation of flow cytometry multilineage score system

Ist Teil von

• Einstein (São Paulo, Brazil), 2020-01, Vol.18, p.eAO4966-eAO4966

Ort / Verlag

Brazil: Instituto Israelita de Ensino e Pesquisa Albert Einstein

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• To validate multilineage score system correlating results of flow cytometry, cytogenetics, cytomorphology and histology from samples of patients with suspected myelodysplastic syndrome or cytopenia of unknown origin. A retrospective study analyzing laboratory data of 49 patients with suspected myelodysplastic syndrome or cytopenia of unknown origin, carried out between May and September 2017. The inclusion criteria were availability of flow cytometry results, and at least one more method, such as morphology, histology or cytogenetics. Thirty-eight patients were classified as diagnosis of myelodysplastic syndromes, whereas 11 were classified as normal. Patients were evaluated based on score systems, Ogata score and flow cytometry multilineage score. Comparing the scores obtained in the Ogata score and the multilineage score, it was observed that in four cases the Ogata score was zero or 1 point, while the multilineage score was higher than 3 points. In addition, in 12 cases with Ogata score of 2, the multilineage score was greater than 3. The flow cytometry multilineage score system demonstrated to be more effective in dysplasia analysis, by assessing the erythroid, monocytic, granulocytic and precursor cell lineages, apart from the parameters evaluated by the Ogata score.