Details

Autor(en) / Beteiligte

• Chang, Yun Min
• Donovan, Michael J.
• Tan, Weihong
• Kuwahara, Masayasu

Titel

Using Aptamers for Cancer Biomarker Discovery

Ist Teil von

• Journal of Nucleic Acids, 2013-01, Vol.2013 (2013), p.104-110

Ort / Verlag

Cairo, Egypt: Hindawi Limiteds

Erscheinungsjahr

2013

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Aptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules. Aptamers have high affinity and high specificity that are comparable to that of antibodies. They are obtained using iterative method, called (Systematic Evolution of Ligands by Exponential Enrichment) SELEX and cell-based SELEX (cell-SELEX). Aptamers can be paired with recent advances in nanotechnology, microarray, microfluidics, and other technologies for applications in clinical medicine. One particular area that aptamers can shed a light on is biomarker discovery. Biomarkers are important in diagnosis and treatment of cancer. In this paper, we will describe ways in which aptamers can be used to discover biomarkers for cancer diagnosis and therapeutics.