Details

Autor(en) / Beteiligte

• Lang, Raynell
• Humes, Elizabeth
• Hogan, Brenna
• Lee, Jennifer
• D'Agostino, Ralph
• Massaro, Joseph
• Kim, Arthur
• Meigs, James B
• Borowsky, Leila
• He, Wei
• Lyass, Asya
• Cheng, David
• Kim, H Nina
• Klein, Marina B
• Cachay, Edward R
• Bosch, Ronald J
• Gill, M John
• Silverberg, Michael J
• Thorne, Jennifer E
• McGinnis, Kathleen
• Horberg, Michael A
• Sterling, Timothy R
• Triant, Virginia A
• Althoff, Keri N

Titel

Evaluating the Cardiovascular Risk in an Aging Population of People With HIV: The Impact of Hepatitis C Virus Coinfection

Ist Teil von

• Journal of the American Heart Association, 2022-10, Vol.11 (19), p.e026473-e026473

Ort / Verlag

England: John Wiley and Sons Inc

Erscheinungsjahr

2022

Quelle

Wiley HSS Collection

Beschreibungen/Notizen

• Background People with HIV (PWH) are at an increased risk of cardiovascular disease (CVD) with an unknown added impact of hepatitis C virus (HCV) coinfection. We aimed to identify whether HCV coinfection increases the risk of type 1 myocardial infarction (T1MI) and if the risk differs by age. Methods and Results We used data from NA-ACCORD (North American AIDS Cohort Collaboration on Research and Design) from January 1, 2000, to December 31, 2017, PWH (aged 40-79 years) who had initiated antiretroviral therapy. The primary outcome was an adjudicated T1MI event. Those who started direct-acting HCV antivirals were censored at the time of initiation. Crude incidence rates per 1000 person-years were calculated for T1MI by calendar time. Discrete time-to-event analyses with complementary log-log models were used to estimate adjusted hazard ratios and 95% CIs for T1MI among those with and without HCV. Among 23 361 PWH, 4677 (20%) had HCV. There were 89 (1.9%) T1MIs among PWH with HCV and 314 (1.7%) among PWH without HCV. HCV was not associated with increased T1MI risk in PWH (adjusted hazard ratio, 0.98 [95% CI, 0.74-1.30]). However, the risk of T1MI increased with age and was amplified in those with HCV (adjusted hazard ratio per 10-year increase in age, 1.85 [95% CI, 1.38-2.48]) compared with those without HCV (adjusted hazard ratio per 10-year increase in age,1.30 [95% CI, 1.13-1.50]; <0.001, test of interaction). Conclusions HCV coinfection was not significantly associated with increased T1MI risk; however, the risk of T1MI with increasing age was greater in those with HCV compared with those without, and HCV status should be considered when assessing CVD risk in aging PWH.