Molecular cancer, 2023-03, Vol.22 (1), p.49-49, Article 49
2023
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Details
- Autor(en) / Beteiligte
- Titel
- Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
- Ist Teil von
- Molecular cancer, 2023-03, Vol.22 (1), p.49-49, Article 49
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2023
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) - a highly aggressive pediatric cancer - mainly arises. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is the principal molecular mediator of the hypoxic response in cancer whereas EWSR1::FLI1 constitutes the oncogenic driver of EwS. Interaction of the two proteins has been shown in EwS. Although a growing body of studies investigated hypoxia and HIFs in EwS, their precise role for EwS pathophysiology is not clarified to date. This review summarizes and structures recent findings demonstrating that hypoxia and HIFs play a role in EwS at multiple levels. We propose to view hypoxia and HIFs as independent protagonists in the story of EwS and give a perspective on their potential clinical relevance as prognostic markers and therapeutic targets in EwS treatment.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1476-4598eISSN: 1476-4598DOI: 10.1186/s12943-023-01750-wTitel-ID: cdi_doaj_primary_oai_doaj_org_article_1e0ec40abe78487a8e5714fd7e4561d0
- Format
- –
- Schlagworte
- Apoptosis, ARNT, Cancer, Cell cycle, Cell growth, Cell Line, Tumor, Child, Ewing sarcoma, Ewing's sarcoma, Ewings sarcoma, FLI-1 protein, Gene Expression Regulation, Neoplastic, Genotype & phenotype, HIF-1-a, HIF-1-b, Humans, Hypoxia, Hypoxia - genetics, Kinases, Oncogene Proteins, Fusion - genetics, Oxygen tension, Pathophysiology, Pediatrics, Proteins, Proteins - metabolism, Review, RNA-Binding Protein EWS - genetics, RNA-Binding Protein EWS - metabolism, Sarcoma, Sarcoma, Ewing - genetics, Sarcoma, Ewing - pathology, Solid tumors, Therapeutic targets, Transcription factors, Tumor Microenvironment, Tumors