Neural regeneration research, 2016-07, Vol.11 (7), p.1128-1133
2016
Details
- Autor(en) / Beteiligte
- Titel
- Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury
- Ist Teil von
- Neural regeneration research, 2016-07, Vol.11 (7), p.1128-1133
- Ort / Verlag
- India: Wolters Kluwer - Medknow Publications
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The adipocytokine,apelin-13,is an abundantly expressed peptide in the nervous system.Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy.However,secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear.Here,we found that apelin-13 significantly decreases cerebral water content,mitigates blood-brain barrier destruction,reduces aquaporin-4 expression,diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus,and reduces apoptosis.These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1673-5374eISSN: 1876-7958DOI: 10.4103/1673-5374.187049Titel-ID: cdi_doaj_primary_oai_doaj_org_article_1cfb6e561cf444fb8b6be8f6aeb85d11
- Format
- –
- Schlagworte
- Analysis, Apoptosis, Autophagy (Cytology), Brain injuries, Caspase-3, Edema, Laboratory animals, nerve regeneration, apoptosis, apelin-13, traumatic brain injury, brain edema, blood-brain barrier, brain water content, aquaporin-4, caspase-3, neural regeneration, Nervous system, Proteins, Risk factors, Traumatic brain injury, 创伤性脑损伤, 水通道蛋白4, 神经保护作用, 神经细胞死亡, 继发性, 缺血/再灌注损伤, 血脑屏障