Details

Autor(en) / Beteiligte

• Li, Huayao
• Gao, Chundi
• Liu, Cun
• Liu, Lijuan
• Zhuang, Jing
• Yang, Jing
• Zhou, Chao
• Feng, Fubin
• Sun, Changgang
• Wu, Jibiao

Titel

A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen

Ist Teil von

• Biomedicine & pharmacotherapy, 2021-05, Vol.137, p.111332, Article 111332

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• [Display omitted] •The structure, pharmacokinetics and pharmacological activities of cryptotanshinone.•The molecular target of cryptotanshinone and its intervention pathway mechanism.•Cryptotanshinoneh has anti-cancer, anti-inflammatory and immunomodulatory effects.•Cryptotanshinone interferes with cancer through JAK2/STAT3, PI3K/AKT pathway. Cryptotanshinone (IUPAC name: (R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione), a biologically active constituent extracted from the roots and rhizomes of the plant Salvia miltiorrhiza, has been studied in depth as a medicinally active compound and shown to have efficacy in the treatment of numerous diseases and disorders. In this review, we describe in detail the current status of cryptotanshinone research, including findings relating to the structure, pharmacokinetics, pharmacological activity, and derivatives of this compound. Cryptotanshinoneh as a diverse range of pharmacological effects, including anti-cancer, anti-inflammatory, immune regulatory, neuroprotective, and anti-fibrosis activities. Studies on the molecular mechanisms underlying the activities of cryptotanshinone have established that the JAK2/STAT3, PI3K/AKT, NF-κB, AMPK, and cell cycle pathways are involved in the inhibitory and pro-apoptotic effects of cryptotanshinone on different tumor cell lines, these molecular pathways interact in a coordinated manner to inhibit cell proliferation, migration and invasion,and induce transformation, autophagy, necrosis, and cellular immunity. The anti-inflammatory mechanisms of cryptotanshinone have been found to be associated with the TLR4-MyD88/PI3K/Nrf2 and TLR4-MyD88/NF-κB/MAPK pathways, whereasthe Hedgehog, NF-κB, and Nrf-2/HO-1 pathways are regulated by cryptotanshinone to reduce organ fibrosis, and its inhibitory effects on the PI3K/AKT-eNOS pathway have been linked to neuroprotective effects. Given the potential medicinal utility of cryptotanshinone, further research is needed to verify the efficacy and safety of this compound in clinical use, evaluate its pharmacological activity, and identify molecular targets.