Details

Autor(en) / Beteiligte

• Nikitina, T.V.
• Menzorov, A.G.
• Kashevarova, A.A.
• Gridina, M.M.
• Khabarova, A.A.
• Yakovleva, Yu.S.
• Lopatkina, M.E.
• Pristyazhnyuk, I.E.
• Vasilyev, S.A.
• Serov, O.L.
• Lebedev, I.N.

Titel

Induced pluripotent stem cell line, IMGTi003-A, derived from skin fibroblasts of an intellectually disabled patient with ring chromosome 13

Ist Teil von

• Stem cell research, 2018-12, Vol.33, p.260-264

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2018

Link zum Volltext

Quelle

ScienceDirect Journals (5 years ago - present)

Beschreibungen/Notizen

• Skin fibroblasts from a patient with neurodevelopmental and speech delay, anxiety disorder, macrocephaly, microorchidism, multiple anomalies of internal organs and ring chromosome 13 were reprogrammed into induced pluripotent stem cells (iPSCs) to generate a clonal stem cell line IMGTi003-A (iTAF6-6). IMGTi003-A pluripotency was demonstrated by three germ layer differentiation capacity in vitro, and this cell line had a mosaic karyotype with 46,XY,r(13) as a predominant cell subpopulation. IMGTi003-A line is a good model for studying of the mitotic instability of the ring chromosome 13.