Details

Autor(en) / Beteiligte

• Giannopapas, Vasileios
• Stefanou, Maria-Ioanna
• Smyrni, Vassiliki
• Kitsos, Dimitrios K
• Kosmidou, Maria
• Stasi, Sophia
• Chasiotis, Athanasios K
• Stavrogianni, Konstantina
• Papagiannopoulou, Georgia
• Tzartos, John S
• Paraskevas, George P
• Tsivgoulis, Georgios
• Giannopoulos, Sotirios

Titel

Waist Circumference and Body Mass Index as Predictors of Disability Progression in Multiple Sclerosis: A Systematic Review and Meta-Analysis

Ist Teil von

• Journal of clinical medicine, 2024-03, Vol.13 (6), p.1739

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• While obesity has been shown to elevate the risk of developing multiple sclerosis (MS), there is a lack of strong evidence regarding its role in the disability progression and status of MS patients. This systematic review and meta-analysis aimed to provide comparative estimates of WC and BMI in patients with MS (PwMS) and to investigate potential associations between the waist circumference (WC) and body mass index (BMI) and demographic and specific MS characteristics. Adhering to PRISMA guidelines, a detailed search of the MEDLINE PubMed, Cochrane Library, and Scopus databases was conducted. A total of 16 studies were included. The pooled mean WC and BMI among PwMS was estimated to be 87.27 cm (95%CI [84.07; 90.47]) and 25.73 (95%CI [25.15; 26.31]), respectively. Meta-regression models established a significant bidirectional relationship between WC and the Expanded Disability Scale (EDSS) ( < 0.001) but not between BMI and EDSS ( = 0.45). Sensitivity analyses showed no association between WC and age ( = 0.48) and a tendency between WC and disease duration ( = 0.08). Although WC measurements classify PwMS as normal weight, BMI measurements classify them as overweight. Therefore, WC should complement BMI evaluations in clinical practice. Additionally, our findings highlight the significant association between abdominal fat, as indicated by WC, and disease progression. Considering the heightened risk of cardiovascular comorbidity and mortality among PwMS, we recommend integrating both WC and BMI as standard anthropometric measurements in routine clinical examinations and targeted prevention strategies for PwMS.