Details

Autor(en) / Beteiligte

• Geneugelijk, Kirsten
• Thus, Kirsten Anne
• Spierings, Eric
• Huyton, Trevor

Titel

Predicting Alloreactivity in Transplantation

Ist Teil von

• Journal of Immunology Research, 2014-01, Vol.2014, p.159479-12

Ort / Verlag

Egypt: Hindawi Publishing Corporation

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Human leukocyte Antigen (HLA) mismatching leads to severe complications after solid-organ transplantation and hematopoietic stem-cell transplantation. The alloreactive responses underlying the posttransplantation complications include both direct recognition of allogeneic HLA by HLA-specific alloantibodies and T cells and indirect T-cell recognition. However, the immunogenicity of HLA mismatches is highly variable; some HLA mismatches lead to severe clinical B-cell- and T-cell-mediated alloreactivity, whereas others are well tolerated. Definition of the permissibility of HLA mismatches prior to transplantation allows selection of donor-recipient combinations that will have a reduced chance to develop deleterious host-versus-graft responses after solid-organ transplantation and graft-versus-host responses after hematopoietic stem-cell transplantation. Therefore, several methods have been developed to predict permissible HLA-mismatch combinations. In this review we aim to give a comprehensive overview about the current knowledge regarding HLA-directed alloreactivity and several developed in vitro and in silico tools that aim to predict direct and indirect alloreactivity.