Details

Autor(en) / Beteiligte

• Rodriguez, Lucie
• Pekkarinen, Pirkka T.
• Lakshmikanth, Tadepally
• Tan, Ziyang
• Consiglio, Camila Rosat
• Pou, Christian
• Chen, Yang
• Mugabo, Constantin Habimana
• Nguyen, Ngoc Anh
• Nowlan, Kirsten
• Strandin, Tomas
• Levanov, Lev
• Mikes, Jaromir
• Wang, Jun
• Kantele, Anu
• Hepojoki, Jussi
• Vapalahti, Olli
• Heinonen, Santtu
• Kekäläinen, Eliisa
• Brodin, Petter

Titel

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

Ist Teil von

• Cell reports. Medicine, 2020-08, Vol.1 (5), p.100078-100078, Article 100078

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5–7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFNγ-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19. [Display omitted] Immunomonitoring from acute to recovery phase COVID-19An IFNγ-eosinophil axis precedes lung hyperinflammationBasophils modulate SARS-CoV-2 IgG responsesA shared trajectory of immunological recovery in COVID-19 Immune dysregulation plays a pivotal role during severe COVID-19. Rodriguez et al. present a systems-level, longitudinal study of 37 COVID-19 patients monitored from acute to recovery phases of disease. This study reveals cell-protein dependencies and co-regulated features, as well as a shared immunological trajectory during recovery.