Details

Autor(en) / Beteiligte

• Zhang, Ye
• Kuang, Wei
• Li, Danfeng
• Li, Yu
• Feng, Yi
• Lyu, Xinwei
• Huang, Gao-Bo
• Lian, Jian-Qi
• Yang, Xiao-Fei
• Hu, Cheng
• Xie, Yajuan
• Xue, Song
• Tan, Jiali

Titel

Natural Killer-Like B Cells Secreting Interleukin-18 Induces a Proinflammatory Response in Periodontitis

Ist Teil von

• Frontiers in immunology, 2021-02, Vol.12, p.641562-641562

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Natural killer-like B (NKB) cells, which are newly identified immune subsets, reveal a critical immunoregulatory property in the eradication of microbial infection the secretion of interleukin (IL)-18. For the first time, this study investigated the role of NKB cells in secreting IL-18 in the pathogenesis of periodontitis. In this study, NKB cells' percentage and IL-18 concentration in peripheral blood and periodontium in periodontitis patients was measured using flow cytometry and ELISA. The role of IL-18 in regulating periodontal inflammation was examined in a ( )-induced periodontitis murine model. Peripheral and periodontal-infiltrating CD3 CD19 NKp46 NKB cells, which were the main source of IL-18, were elevated and correlated with attachment loss in periodontitis patients. IL-18 stimulation promoted proinflammatory cytokine production in periodontal ligament cells. infection induced elevation of IL-18 receptor in periodontium in a periodontitis murine model. IL-18 neutralization not only suppressed -induced alveolar bone resorption, but also inhibited recruitment of antigen-non-specific inflammatory cells into the periodontium, probably dampening expressions of cytokines, chemokines, and matrix metalloproteinases. NKB cells secreting IL-18 appeared to be an important mediator in the inflammatory response following intraoral infection. These findings might be relevant to the development of immunotherapies for periodontitis.