Details

Autor(en) / Beteiligte

• Song, Yaolin
• Boncompagni, Ana C.
• Kim, Sang-Seok
• Gochnauer, Heather R.
• Zhang, Yuhang
• Loots, Gabriela G.
• Wu, Dianqing
• Li, Yulin
• Xu, Mingang
• Millar, Sarah E.

Titel

Regional Control of Hairless versus Hair-Bearing Skin by Dkk2

Ist Teil von

• Cell reports (Cambridge), 2018-12, Vol.25 (11), p.2981-2991.e3

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Haired skin is a defining characteristic of mammals. However, some specialized skin regions, such as human palms, soles and ventral wrist, and mouse plantar foot, are entirely hairless. Using mouse plantar skin as a model system, we show that the endogenous secreted Wnt inhibitor DKK2 suppresses plantar hair follicle development and permits the formation of hairless skin. Plantar skin retains all of the mechanistic components needed for hair follicle development, as genetic deletion of Dkk2 permits formation of fully functional plantar hair follicles that give rise to external hair, contain sebaceous glands and a stem cell compartment, and undergo regenerative growth. In the absence of Dkk2, Wnt/β-catenin signaling activity is initially broadly elevated in embryonic plantar skin and gradually becomes patterned, mimicking follicular development in normally haired areas. These data provide a paradigm in which regionally restricted expression of a Wnt inhibitor underlies specification of hairless versus hairy skin. [Display omitted] •DKK2 localizes to embryonic mouse hairless, but not rabbit hairy, plantar skin•Deletion of mouse Dkk2 causes formation of mature, regenerative plantar hair•Dkk2 specifies development of hairless versus hairy skin•Evolutionary changes in Dkk2 regulation underlie species-specific hair patterns What controls formation of hairless versus hairy skin? Song et al. find the secreted Wnt inhibitor Dkk2 is specifically expressed in embryonic mouse hairless, but not in rabbit hair-bearing, plantar skin. Mouse Dkk2 deletion permits plantar hair formation. Thus, evolutionary changes in Dkk2 expression contribute to species-specific hair patterns.