Details

Autor(en) / Beteiligte

• Lin, Wensheng
• Lin, Shixian
• Zhou, Xingwu
• Yang, Fanwen
• Lin, Zishan
• Li, Shiqing
• Zhang, Haoyuan
• Ouyang, Yuehan
• Zhu, Jieying
• Sun, Wei
• Huang, Dequn
• Liao, Baojian
• Zhu, Jixiang

Titel

Biodegradable double-network GelMA-ACNM hydrogel microneedles for transdermal drug delivery

Ist Teil von

• Frontiers in bioengineering and biotechnology, 2023-01, Vol.11, p.1110604-1110604

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• As a minimally invasive drug delivery platform, microneedles (MNs) overcome many drawbacks of the conventional transdermal drug delivery systems, therefore are favorable in biomedical applications. Microneedles with a combined burst and sustained release profile and maintained therapeutic molecular bioactivity could further broaden its applications as therapeutics. Here, we developed a double-network microneedles (DN MNs) based on gelatin methacrylate and acellular neural matrix (GelMA-ACNM). ACNM could function as an early drug release matrix, whereas the addition of GelMA facilitates sustained drug release. In particular, the double-network microneedles comprising GelMA-ACNM hydrogel has distinctive biological features in maintaining drug activity to meet the needs of application in treating different diseases. In this study, we prepared the double-network microneedles and evaluated its morphology, mechanical properties, drug release properties and biocompatibility, which shows great potential for delivery of therapeutic molecules that needs different release profiles in transdermal treatment.