Details

Autor(en) / Beteiligte

• Débare, Héloïse
• Blanc, Fany
• Piton, Guillaume
• Leplat, Jean-Jacques
• Vincent-Naulleau, Silvia
• Rivière, Julie
• Vilotte, Marthe
• Marthey, Sylvain
• Lecardonnel, Jérôme
• Coville, Jean-Luc
• Estellé, Jordi
• Rau, Andrea
• Bourneuf, Emmanuelle
• Egidy, Giorgia

Titel

Malignant features of minipig melanomas prior to spontaneous regression

Ist Teil von

• Scientific reports, 2024-04, Vol.14 (1), p.9240-9240

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In MeLiM minipigs, melanomas develop around birth, can metastasize, and have histopathologic characteristics similar to humans. Interestingly, MeLiM melanomas eventually regress. This favorable outcome raises the question of their malignancy, which we investigated. We clinically followed tens of tumors from onset to first signs of regression. Transcriptome analysis revealed an enrichment of all cancer hallmarks in melanomas, although no activating or suppressing somatic mutation were found in common driver genes. Analysis of tumor cell genomes revealed high mutation rates without UV signature. Canonical proliferative, survival and angiogenic pathways were detected in MeLiM tumor cells all along progression stages. Functionally, we show that MeLiM melanoma cells are capable to grow in immunocompromised mice, with serial passages and for a longer time than in MeLiM pigs. Pigs set in place an immune response during progression with dense infiltration by myeloid cells while melanoma cells are deficient in B2M expression. To conclude, our data on MeLiM melanomas reveal several malignancy characteristics. The combination of these features with the successful spontaneous regression of these tumors make it an outstanding model to study an efficient anti-tumor immune response.