Biomolecules (Basel, Switzerland), 2020-07, Vol.10 (7), p.1040
2020
Details
- Autor(en) / Beteiligte
- Titel
- MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy
- Ist Teil von
- Biomolecules (Basel, Switzerland), 2020-07, Vol.10 (7), p.1040
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Molecular signaling pathways involved in cancer have been intensively studied due to their crucial role in cancer cell growth and dissemination. Among them, zinc finger E-box binding homeobox-1 (ZEB1) and -2 (ZEB2) are molecules that play vital roles in signaling pathways to ensure the survival of tumor cells, particularly through enhancing cell proliferation, promoting cell migration and invasion, and triggering drug resistance. Importantly, ZEB proteins are regulated by microRNAs (miRs). In this review, we demonstrate the impact that miRs have on cancer therapy, through their targeting of ZEB proteins. MiRs are able to act as onco-suppressor factors and inhibit the malignancy of tumor cells through ZEB1/2 down-regulation. This can lead to an inhibition of epithelial-mesenchymal transition (EMT) mechanism, therefore reducing metastasis. Additionally, miRs are able to inhibit ZEB1/2-mediated drug resistance and immunosuppression. Additionally, we explore the upstream modulators of miRs such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as these regulators can influence the inhibitory effect of miRs on ZEB proteins and cancer progression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2218-273XeISSN: 2218-273XDOI: 10.3390/biom10071040Titel-ID: cdi_doaj_primary_oai_doaj_org_article_17aba69cb61a476ba8b4d9bc601d8019
- Format
- –
- Schlagworte
- Apoptosis, Binding proteins, Binding sites, Cancer, Cancer therapies, cancer therapy, Care and treatment, Cell adhesion & migration, Cell cycle, Cell migration, Cell Movement, Cell Proliferation, Cell survival, Chemotherapy, Disease Progression, Drug resistance, Drug Resistance, Neoplasm, EMT, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Genomes, Health aspects, Homeobox, Humans, Immunomodulation, Immunosuppression, immunotherapy, Kinases, Malignancy, Mesenchyme, Metastases, Metastasis, MicroRNA, MicroRNAs, MicroRNAs - genetics, miRNA, Neoplasm Invasiveness, Neoplasms - genetics, Neoplasms - pathology, Non-coding RNA, Ovarian cancer, Pancreatic cancer, Physiological aspects, Proteins, Review, RNA polymerase, Signal transduction, Therapeutic applications, Tumor cells, Wound healing, ZEB family, Zinc Finger E-box Binding Homeobox 2 - genetics, Zinc Finger E-box-Binding Homeobox 1 - genetics, Zinc finger proteins