Details

Autor(en) / Beteiligte

• Hao, Rili
• Ge, Junlin
• Ren, Yongfeng
• Song, Xinyu
• Jiang, Yang
• Sun-Waterhouse, Dongxiao
• Li, Feng
• Li, Dapeng

Titel

Caffeic acid phenethyl ester mitigates cadmium-induced hepatotoxicity in mice: Role of miR-182-5p/TLR4 axis

Ist Teil von

• Ecotoxicology and environmental safety, 2021-01, Vol.207, p.111578, Article 111578

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Cadmium (Cd), an environmental pollutant, is evidenced to cause hepatotoxicity. In this study, the potential protective effect of caffeic acid phenethyl ester (CAPE) on cadmium-induced liver damage was investigated. Forty male mice were treated daily with either CdCl2 (1.5 mg/kg body weight (b.w.), gavage) or CAPE (10 μmol/kg b.w., gavage) or both for 4 weeks. CAPE administration significantly reduced Cd level and liver and body weight, and increased AST, ALT and ALP level. Moreover, CAPE prevented CdCl2-induced oxidative stress via PI3K/Akt/mTOR pathway and inhibited apoptosis by regulating apoptosis markers. CAPE also suppressed the CdCl2-induced inflammation by reducing the inflammatory mediators, including TNF-α, IL-6 and IL-1β. Furthermore, CAPE alleviated CdCl2-induced reduction of TLR4. It should be noted that this effect was achieved by targeting miR-182-5p, and CAPE improved miR-182-5p level. The improvement of the liver tissue histopathology by CAPE confirmed the biochemical data. These results show for the first time that miR-182-5p/TLR4 axis involved in CAPE's protection against CdCl2-induced hepatotoxicity, and may provide novel insights into the treatment of cadmium-related diseases. [Display omitted] •Cadmium induced hepatotoxicity via oxidative stress, inflammatory and apoptosis pathway.•CAPE plays a hepatoprotective role against cadmium induced damage.•MiR-182-5p/TLR4 axis involves in the protection of CAPE against CdCl2-induced hepatotoxicity.