International journal of molecular sciences, 2020-08, Vol.21 (15), p.5583
2020
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- Autor(en) / Beteiligte
- Titel
- The MUDENG Augmentation: A Genesis in Anti-Cancer Therapy?
- Ist Teil von
- International journal of molecular sciences, 2020-08, Vol.21 (15), p.5583
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Despite multitudes of reports on cancer remedies available, we are far from being able to declare that we have arrived at that defining anti-cancer therapy. In recent decades, researchers have been looking into the possibility of enhancing cell death-related signaling pathways in cancer cells using pro-apoptotic proteins. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and Mu-2/AP1M2 domain containing, death-inducing (MUDENG, MuD) have been established for their ability to bring about cell death specifically in cancer cells. Targeted cell death is a very attractive term when it comes to cancer, since most therapies also affect normal cells. In this direction TRAIL has made noteworthy progress. This review briefly sums up what has been done using TRAIL in cancer therapeutics. The importance of MuD and what has been achieved thus far through MuD and the need to widen and concentrate on applicational aspects of MuD has been highlighted. This has been suggested as the future perspective of MuD towards prospective progress in cancer research.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms21155583Titel-ID: cdi_doaj_primary_oai_doaj_org_article_1691e5676ea3488c9c38f95efb029389
- Format
- –
- Schlagworte
- Adaptor Protein Complex 1 - antagonists & inhibitors, Adaptor Protein Complex 1 - genetics, Adaptor Protein Complex mu Subunits - antagonists & inhibitors, Adaptor Protein Complex mu Subunits - genetics, AP5M1, Apoptosis, Apoptosis - drug effects, Apoptosis Regulatory Proteins - antagonists & inhibitors, Apoptosis Regulatory Proteins - genetics, BAX, Cancer, Cancer therapies, Cell death, Cell Proliferation - drug effects, Drug delivery systems, Gene Expression Regulation, Neoplastic - drug effects, Humans, Kinases, Mud, MUDENG, Neoplasms - drug therapy, Neoplasms - genetics, Neoplasms - pathology, Review, Signal Transduction - drug effects, therapy, TNF-Related Apoptosis-Inducing Ligand - antagonists & inhibitors, TNF-Related Apoptosis-Inducing Ligand - genetics, TRAIL, TRAIL protein, Tumor necrosis factor