Details

Autor(en) / Beteiligte

• Hofmaier, Jan
• Walter, Franziska
• Hadi, Indrawati
• Rottler, Maya
• von Bestenbostel, Rieke
• Dedes, George
• Parodi, Katia
• Niyazi, Maximilian
• Belka, Claus
• Kamp, Florian

Titel

Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy

Ist Teil von

• Physics and imaging in radiation oncology, 2021-10, Vol.20, p.117-120

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 × 104 dose recalculations was 59 min. For two patients in this dataset, IOV had a relevant impact on the estimated CTV D95% uncertainty.