Details

Autor(en) / Beteiligte

• Salega, Adrian
• Münch, Marina
• Renner, Philipp
• Thon, Klaus-Peter
• Steurer, Wolfgang
• Mönch, Dina
• Koch, Jana
• Maaß, Annika
• Schlitt, Hans Jürgen
• Dahlke, Marc-Hendrik
• Leibold, Tobias

Titel

Late Local Recurrence after Neoadjuvant Therapy and Radical Resection for Locally Advanced Rectal Cancer

Ist Teil von

• Cancers, 2024-01, Vol.16 (2), p.448

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Neoadjuvant radiochemotherapy (RCT) and lately total neoadjuvant therapy (TNT) improved local recurrence rates of rectal cancer significantly compared to total mesorectal excision (TME) alone. Yet the occurrence and impact of late local recurrences after many years appears to be a distinct biological problem. We included = 188 patients with rectal cancer after RCT and radical resection in this study; = 38 of which had recurrent disease (sites: local (8.0%), liver (6.4%), lung (3.7%)). We found that 68% of all recurrences developed within the first two years. Four patients, however, experience recurrence >8 years after surgery. Here, we report and characterize four cases of late local recurrence (10% of patients with recurrent disease), suggesting that neoadjuvant therapy in principle delays local recurrence.