Details

Autor(en) / Beteiligte

• Wang, Qi-Wei
• Yu, De-Hong
• Lin, Meng-Gan
• Zhao, Mei
• Zhu, Wen-Jun
• Lu, Qin
• Li, Gui-Xiu
• Wang, Chao
• Yang, Yi-Fang
• Qin, Xue-Mei
• Fang, Chao
• Chen, Hong-Zhuan
• Yang, Guo-Hong

Titel

Antiangiogenic polyketides from Peperomia dindygulensis Miq

Ist Teil von

• Molecules (Basel, Switzerland), 2012-04, Vol.17 (4), p.4474-4483

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.