Details

Autor(en) / Beteiligte

• van Es, René
• Konings, Maurits K
• Du Pré, Bastiaan C
• Neven, Kars
• van Wessel, Harry
• van Driel, Vincent J H M
• Westra, Albert H
• Doevendans, Pieter A F
• Wittkampf, Fred H M

Titel

High-frequency irreversible electroporation for cardiac ablation using an asymmetrical waveform

Ist Teil von

• Biomedical engineering online, 2019-06, Vol.18 (1), p.75-75, Article 75

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2019

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Irreversible electroporation (IRE) using direct current (DC) is an effective method for the ablation of cardiac tissue. A major drawback of the use of DC-IRE, however, are two problems: requirement of general anesthesia due to severe muscle contractions and the formation of bubbles containing gaseous products from electrolysis. The use of high-frequency alternating current (HF-IRE) is expected to solve both problems, because HF-IRE produces little to no muscle spasms and does not cause electrolysis. In the present study, we introduce a novel asymmetric, high-frequency (aHF) waveform for HF-IRE and present the results of a first, small, animal study to test its efficacy. The data of the experiments suggest that the aHF waveform creates significantly deeper lesions than a symmetric HF waveform of the same energy and frequency (p = 0.003). We therefore conclude that the use of the aHF enhances the feasibility of the HF-IRE method.