Details

Autor(en) / Beteiligte

• Haag, Maria
• Wells, Kevin
• Lamberson, William

Titel

Genetic basis of voluntary water consumption in two divergently selected strains of inbred mice

Ist Teil von

• Veterinary medicine and science, 2019-11, Vol.5 (4), p.569-573

Ort / Verlag

England: John Wiley & Sons, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Background Inbred mouse strains with normal renal function show a substantial difference in daily water consumption across strains. This study uses two strains of inbred mice C57BR/CDJ (BR), which are high consumers, and C57BL/10J (BL), which are low consumers, their reciprocal F1 crosses, inter se bred F2s and backcrosses produced by breeding high consuming F2 animals to the low consumer parent strain and low consuming F2 animals to the high consuming parent strain. Consumption was corrected for body weight prior to analysis. Methods The effective number of genes controlling water consumption was estimated using the Castle–Wright estimator. Additive and dominance genotypic values as well as the degree of dominance were calculated using estimated strain means. Results According to Castle–Wright, a minimum of 10 factors were estimated to affect the difference in consumption across the two strains. Between seven and eight are expected to be high effect factors. Using the Zeng adjustment, it was determined that 30–40 factors potentially affect the difference in consumption. Conclusions These numbers were surprising but may be related to several sources of variation present in the BR strain. A negative degree of dominance indicated the BL strain has more dominant factors.