Details

Autor(en) / Beteiligte

• Zhong, Mingliang
• Wu, Zhenyu
• Chen, Zhixi
• Ren, Qun
• Zhou, Jianguo

Titel

Advances in the interaction between endoplasmic reticulum stress and osteoporosis

Ist Teil von

• Biomedicine & pharmacotherapy, 2023-09, Vol.165, p.115134-115134, Article 115134

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The endoplasmic reticulum (ER) is the main site for protein synthesis, folding, and secretion, and accumulation of the unfolded/misfolded proteins in the ER may induce ER stress. ER stress is an important participant in various intracellular signaling pathways. Prolonged- or high-intensity ER stress may induce cell apoptosis. Osteoporosis, characterized by imbalanced bone remodeling, is a global disease caused by many factors, such as ER stress. ER stress stimulates osteoblast apoptosis, increases bone loss, and promotes osteoporosis development. Many factors, such as the drug’s adverse effects, metabolic disorders, calcium ion imbalance, bad habits, and aging, have been reported to activate ER stress, resulting in the pathological development of osteoporosis. Increasing evidence shows that ER stress regulates osteogenic differentiation, osteoblast activity, and osteoclast formation and function. Various therapeutic agents have been developed to counteract ER stress and thereby suppress osteoporosis development. Thus, inhibition of ER stress has become a potential target for the therapeutic management of osteoporosis. However, the in-depth understanding of ER stress in the pathogenesis of osteoporosis still needs more effort. [Display omitted] •ER stress is implicated in bone remodeling.•ER stress mediates osteogenic differentiation and osteoblast activity.•ER stress regulates osteoclast formation and function.•ER stress has become a target for osteoporosis treatment.