International journal of molecular sciences, 2018-02, Vol.19 (2), p.588
2018
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- Autor(en) / Beteiligte
- Titel
- New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome
- Ist Teil von
- International journal of molecular sciences, 2018-02, Vol.19 (2), p.588
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Acute respiratory distress syndrome is an inflammatory disease characterized by dysfunction of pulmonary epithelial and capillary endothelial cells, infiltration of alveolar macrophages and neutrophils, cell apoptosis, necroptosis, NETosis, and fibrosis. Inflammatory responses have key effects on every phase of acute respiratory distress syndrome. The severe inflammatory cascades impaired the regulation of vascular endothelial barrier and vascular permeability. Therefore, understanding the relationship between the molecular regulation of immune cells and the pulmonary microenvironment is critical for disease management. This article reviews the current clinical and basic research on the pathogenesis of acute respiratory distress syndrome, including information on the microenvironment, vascular endothelial barrier and immune mechanisms, to offer a strong foundation for developing therapeutic interventions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms19020588Titel-ID: cdi_doaj_primary_oai_doaj_org_article_117ac57b58664aa3b489d087ed25fa8b
- Format
- –
- Schlagworte
- acute respiratory distress syndrome, Alveoli, Animals, Apoptosis, Capillary Permeability, Cascades, Disease control, Endothelial cells, Endothelium, Vascular - metabolism, Fibrosis, Humans, Immune system, Inflammation, Leukocytes (neutrophilic), Macrophages, Molecular biology, Necroptosis, NETosis, Pathogenesis, Permeability, Respiratory distress syndrome, Respiratory Distress Syndrome, Adult - drug therapy, Respiratory Distress Syndrome, Adult - etiology, Respiratory Distress Syndrome, Adult - immunology, Respiratory therapy, Review, sepsis, Signal Transduction, Smoke inhalation, Therapeutic applications, vascular permeability