Details

Autor(en) / Beteiligte

• Chruściel, Elżbieta
• Urban-Wójciuk, Zuzanna
• Arcimowicz, Łukasz
• Kurkowiak, Małgorzata
• Kowalski, Jacek
• Gliwiński, Mateusz
• Marjański, Tomasz
• Rzyman, Witold
• Biernat, Wojciech
• Dziadziuszko, Rafał
• Montesano, Carla
• Bernardini, Roberta
• Marek-Trzonkowska, Natalia

Titel

Adoptive Cell Therapy-Harnessing Antigen-Specific T Cells to Target Solid Tumours

Ist Teil von

• Cancers, 2020-03, Vol.12 (3), p.683

Ort / Verlag

Switzerland: MDPI

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells as therapeutic tools. Immunotherapy with T cells expressing chimeric antigen receptors (CARs) demonstrated great success in the treatment of haematologic malignancies, whereas adoptive transfer of autologous tumour infiltrating lymphocytes (TILs) proved to be highly effective in metastatic melanoma. These encouraging results initiated many studies where ACT was tested as a treatment for various solid tumours. In this review, we provide an overview of the challenges of T cell-based immunotherapies of solid tumours. We describe alternative approaches for choosing the most efficient T cells for cancer treatment in terms of their tumour-specificity and phenotype. Finally, we present strategies for improvement of anti-tumour potential of T cells, including combination therapies.