Details

Autor(en) / Beteiligte

• Spicer, James
• Basu, Bristi
• Montes, Ana
• Banerji, Udai
• Kristeleit, Rebecca
• Miller, Rowan
• Veal, Gareth J
• Corrigan, Christopher J
• Till, Stephen J
• Figini, Mariangela
• Canevari, Silvana
• Barton, Claire
• Jones, Paul
• Mellor, Sarah
• Carroll, Simon
• Selkirk, Chris
• Nintos, George
• Kwatra, Vineet
• Funingana, Ionut-Gabriel
• Doherty, Gary
• Gould, Hannah J
• Pellizzari, Giulia
• Nakamura, Mano
• Ilieva, Kristina M
• Khiabany, Atousa
• Stavraka, Chara
• Chauhan, Jitesh
• Gillett, Cheryl
• Pinder, Sarah
• Bax, Heather J
• Josephs, Debra H
• Karagiannis, Sophia N

Titel

Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial

Ist Teil von

• Nature communications, 2023-07, Vol.14 (1), p.4180-4180

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT02546921) with the primary objective of exploring the safety and tolerability of MOv18 IgE, a chimeric first-in-class IgE antibody, in patients with tumours expressing the relevant antigen, folate receptor-alpha. The trial incorporated skin prick and basophil activation tests (BAT) to select patients at lowest risk of allergic toxicity. Secondary objectives were exploration of anti-tumour activity, recommended Phase II dose, and pharmacokinetics. Dose escalation ranged from 70 μg-12 mg. The most common toxicity of MOv18 IgE is transient urticaria. A single patient experienced anaphylaxis, likely explained by detection of circulating basophils at baseline that could be activated by MOv18 IgE. The BAT assay was used to avoid enrolling further patients with reactive basophils. The safety profile is tolerable and maximum tolerated dose has not been reached, with evidence of anti-tumour activity observed in a patient with ovarian cancer. These results demonstrate the potential of IgE therapy for cancer.