Details

Autor(en) / Beteiligte

• Øen, Silje Kjærnes
• Keil, Thomas Morten
• Berntsen, Erik Magnus
• Aanerud, Joel Fredrik
• Schwarzlmüller, Thomas
• Ladefoged, Claes Nøhr
• Karlberg, Anna Maria
• Eikenes, Live

Titel

Quantitative and clinical impact of MRI-based attenuation correction methods in [18F]FDG evaluation of dementia

Ist Teil von

• EJNMMI research, 2019-08, Vol.9 (1), p.83-12, Article 83

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2019

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Background Positron emission tomography/magnetic resonance imaging (PET/MRI) is a promising diagnostic imaging tool for the diagnosis of dementia, as PET can add complementary information to the routine imaging examination with MRI. The purpose of this study was to evaluate the influence of MRI-based attenuation correction (MRAC) on diagnostic assessment of dementia with [ 18 F]FDG PET. Quantitative differences in both [ 18 F]FDG uptake and z-scores were calculated for three clinically available (DixonNoBone, DixonBone, UTE) and two research MRAC methods (UCL, DeepUTE) compared to CT-based AC (CTAC). Furthermore, diagnoses based on visual evaluations were made by three nuclear medicine physicians and one neuroradiologist (PET CT , PET DeepUTE , PET DixonBone , PET UTE , PET CT + MRI, PET DixonBone + MRI). In addition, pons and cerebellum were compared as reference regions for normalization. Results The mean absolute difference in z-scores were smallest between MRAC and CTAC with cerebellum as reference region: 0.15 ± 0.11 σ (DeepUTE), 0.15 ± 0.12 σ (UCL), 0.23 ± 0.20 σ (DixonBone), 0.32 ± 0.28 σ (DixonNoBone), and 0.54 ± 0.40 σ (UTE). In the visual evaluation, the diagnoses agreed with PET CT in 74% (PET DeepUTE ), 67% (PET DixonBone ), and 70% (PET UTE ) of the patients, while PET CT + MRI agreed with PET DixonBone + MRI in 89% of the patients. Conclusion The MRAC research methods performed close to that of CTAC in the quantitative evaluation of [ 18 F]FDG uptake and z-scores. Among the clinically implemented MRAC methods, Dixon Bone should be preferred for diagnostic assessment of dementia with [ 18 F]FDG PET/MRI. However, as artifacts occur in Dixon Bone attenuation maps, they must be visually inspected to assure proper quantification.