Details

Autor(en) / Beteiligte

• Monti-Rocha, Renata
• Cramer, Allysson
• Gaio Leite, Paulo
• Antunes, Maísa Mota
• Pereira, Rafaela Vaz Sousa
• Barroso, Andréia
• Queiroz-Junior, Celso M
• David, Bruna Araújo
• Teixeira, Mauro Martins
• Menezes, Gustavo Batista
• Machado, Fabiana Simão

Titel

SOCS2 Is Critical for the Balancing of Immune Response and Oxidate Stress Protecting Against Acetaminophen-Induced Acute Liver Injury

Ist Teil von

• Frontiers in immunology, 2019-01, Vol.9, p.3134-3134

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2019

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Acetaminophen (APAP) is usually safe when administrated in therapeutic doses; however, APAP overdose can lead to severe liver injury. APAP can cause direct hepatocyte damage, and stimulates an inflammatory response leading to oxidative stress. Supressor of Cytokine Signaling (SOCS) 2 modulates cytokine and growth factor signaling, and plays a role in the regulation of hepatic cellular processes. Our study evaluated the role of SOCS2 in APAP liver injury. The administration of a toxic dose (600 mg/kg) of APAP caused significant liver necrosis in WT mice. In SOCS2 mice, there was significantly more necrosis, neutrophil recruitment, and expression of the neutrophil-active chemokine CXCL-1. Expression of proinflammatory cytokines, such as TNF-α and IL-6, was elevated, while expression of anti-inflammatory cytokines, IL-10 and TGF-β, was diminished. , SOCS2 hepatocytes expressed more p-NF-kB and produced more ROS than WT hepatocytes when exposed to APAP. SOCS2 hepatocytes were more sensitive to cell death in the presence of IL-6 and hydrogen peroxide. The administration of catalase and resulted in a pronounced reduction of cells/mice death and necrosis in the SOCS2 group. We have demonstrated that SOCS2 has a protective role in the liver by controlling pro-oxidative and inflammatory mechanisms induced by APAP.