Details

Autor(en) / Beteiligte

• Yepes-Calderón, Manuela
• Kremer, Daan
• Post, Adrian
• Sotomayor, Camilo G
• Seidel, Ulrike
• Huebbe, Patricia
• Knobbe, Tim J
• Lüersen, Kai
• Eisenga, Michele F
• Corpeleijn, Eva
• De Borst, Martin H
• Navis, Gerjan J
• Rimbach, Gerald
• Bakker, Stephan J L

Titel

Plasma Copper Concentration Is Associated with Cardiovascular Mortality in Male Kidney Transplant Recipients

Ist Teil von

• Antioxidants, 2023-02, Vol.12 (2), p.454

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Kidney transplant recipients (KTR) are at increased risk of cardiovascular mortality. We investigated whether, in KTR, post-transplantation copper status is associated with the risk of cardiovascular mortality and potential effect modification by sex. In this cohort study, plasma copper was measured using mass spectrometry in extensively-phenotyped KTR with a functioning allograft >1-year. Cox regression analyses with the inclusion of multiplicative interaction terms were performed. In 660 KTR (53 ± 13 years old, 56% male), the median baseline plasma copper was 15.42 (IQR 13.53-17.63) µmol/L. During a median follow-up of 5 years, 141 KTR died, 53 (38%) due to cardiovascular causes. Higher plasma copper was associated with an increased risk of cardiovascular mortality in the overall KTR population (HR 1.37; 95% CI, 1.07-1.77 per 1-SD, = 0.01). Sex was a significant effect modifier of this association (P = 0.01). Among male KTR, higher plasma copper concentration was independently associated with a two-fold higher risk of cardiovascular mortality (HR 2.09; 95% CI, 1.42-3.07 per 1-SD, < 0.001). Among female KTR, this association was absent. This evidence offers a rationale for considering a sex-specific assessment of copper's role in cardiovascular risk evaluation. Further studies are warranted to elucidate whether copper-targeted interventions may decrease cardiovascular mortality in male KTR.