Arthritis research & therapy, 2022-01, Vol.24 (1), p.35-35, Article 35
2022
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- Autor(en) / Beteiligte
- Titel
- Role of the S100 protein family in rheumatoid arthritis
- Ist Teil von
- Arthritis research & therapy, 2022-01, Vol.24 (1), p.35-35, Article 35
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma). The destruction of joints and surrounding tissues eventually causes joint deformities and dysfunction or even loss. The S100 protein family is one of the biggest subtribes in the calcium-binding protein family and has more than 20 members. The overexpression of most S100 proteins in rheumatoid arthritis is closely related to its pathogenesis. This paper reviews the relationship between S100 proteins and the occurrence and development of rheumatoid arthritis. It will provide insights into the development of new clinical diagnostic markers and therapeutic targets for rheumatoid arthritis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1478-6362, 1478-6354eISSN: 1478-6362DOI: 10.1186/s13075-022-02727-8Titel-ID: cdi_doaj_primary_oai_doaj_org_article_0eb81d54cfef4326b346ef0fa375d541
- Format
- –
- Schlagworte
- Amino acids, Arthritis, Arthritis, Rheumatoid - pathology, Binding sites, Biomarkers, Bone erosion, Bone marrow, Calcium-binding proteins, Cell cycle, Chemokines, Cytokines, Cytoplasm, Development and progression, Diagnosis, Fibroblasts, Gene expression, Granulocytes, Granulomas, Health aspects, Humans, Inflammation, Kinases, Ligands, Medical diagnosis, Molecular weight, Neutrophils, Pannus formation, Proteins, Review, Rheumatoid arthritis, Risk factors, S100 protein, S100 Proteins - genetics, S100 Proteins - metabolism, Signal transduction, Synovial inflammation, Synovial Membrane - metabolism, Tumor necrosis factor-TNF