Details

Autor(en) / Beteiligte

• Costa, Giuliano
• D'Errigo, Paola
• Rosato, Stefano
• Biancari, Fausto
• Marcellusi, Andrea
• Tarantini, Giuseppe
• Santoro, Gennaro
• Baiocchi, Massimo
• Maffeo, Diego
• Fiorina, Claudia
• Cerza, Francesco
• Baglio, Giovanni
• Juvonen, Tatu
• Badoni, Gabriella
• Valvo, Roberto
• Seccareccia, Fulvia
• Barbanti, Marco
• Tamburino, Corrado
• On Behalf Of The Observant Ii Research Group

Titel

One-Year Outcomes and Trends over Two Eras of Transcatheter Aortic Valve Implantation in Real-World Practice

Ist Teil von

• Journal of clinical medicine, 2022-02, Vol.11 (5), p.1164

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Data reflecting the benefit of procedural improvements in real-world transcatheter aortic valve implantation (TAVI) practice are sparse. To compare outcomes and trends of two TAVI eras from real Italian practice. A total of 1811 and 2939 TAVI patients enrolled in the national, prospective OBSERVANT and OBSERVANT II studies in 2010-2012 and 2016-2018, respectively, were compared in a cohort study. Outcomes were adjusted using inverse propensity of treatment weighting and propensity score matching. The median age (83.0 (79.0-86.0) vs. 83.0 (79.0-86.0)) and EuroSCORE II (5.2 (3.2-7.7) vs. 5.1 (3.1-8.1)) of OBSERVANT and OBSERVANT II patients were similar. At 1 year, patients of the OBSERVANT II study had a significantly lower risk of all-cause death (10.6% vs. 16.3%, Hazard Ratio (HR) 0.63 (95% Confidence Interval (CI) 0.52-0.76)) and rehospitalization for heart failure (HF) (14.3% vs. 19.5%, Sub-distribution HR 0.71 (95%CI 0.60-0.84)), whereas rates of stroke (3.1% vs. 3.6%) and permanent pacemaker implantation (PPI) (16.6% vs. 18.0%) were comparable between study groups. Age and risk profile among patients undergoing TAVI in Italy remained substantially unchanged between the 2010-2012 and 2016-2018 time periods. After adjustment, patients undergoing TAVI in the most recent era had lower risk of all-cause death and rehospitalization for HF at 1 year, whereas rates of stroke and PPI did not differ significantly.