Details

Autor(en) / Beteiligte

• Belvindrah, Richard
• Nosten-Bertrand, Marika
• Francis, Fiona

Titel

Neuronal migration and its disorders affecting the CA3 region

Ist Teil von

• Frontiers in cellular neuroscience, 2014-03, Vol.8, p.63-63

Ort / Verlag

Switzerland: Frontiers Research Foundation

Erscheinungsjahr

2014

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• In this review, we focus on CA3 neuronal migration disorders in the rodent. We begin by introducing the main steps of hippocampal development, and we summarize characteristic hippocampal malformations in human. We then describe various mouse mutants showing structural hippocampal defects. Notably, genes identified in human cortical neuronal migration disorders consistently give rise to a CA3 phenotype when mutated in the mouse. We successively describe their molecular, physiological and behavioral phenotypes that together contribute to a better understanding of CA3-dependent functions. We finally discuss potential factors underlying the CA3 vulnerability revealed by these mouse mutants and that may also contribute to other human neurological and psychiatric disorders.