Details

Autor(en) / Beteiligte

• Nqoro, Xhamla
• Tobeka, Naki
• Aderibigbe, Blessing A

Titel

Quinoline-Based Hybrid Compounds with Antimalarial Activity

Ist Teil von

• Molecules (Basel, Switzerland), 2017-12, Vol.22 (12), p.2268

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2017

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The application of quinoline-based compounds for the treatment of malaria infections is hampered by drug resistance. Drug resistance has led to the combination of quinolines with other classes of antimalarials resulting in enhanced therapeutic outcomes. However, the combination of antimalarials is limited by drug-drug interactions. In order to overcome the aforementioned factors, several researchers have reported hybrid compounds prepared by reacting quinoline-based compounds with other compounds via selected functionalities. This review will focus on the currently reported quinoline-based hybrid compounds and their preclinical studies.