Details

Autor(en) / Beteiligte

• Tsukamoto, Tetsuya
• Nakagawa, Mitsuru
• Kiriyama, Yuka
• Toyoda, Takeshi
• Cao, Xueyuan

Titel

Prevention of Gastric Cancer: Eradication of Helicobacter Pylori and Beyond

Ist Teil von

• International journal of molecular sciences, 2017-08, Vol.18 (8), p.1699

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.