Details

Autor(en) / Beteiligte

• Ming, Dongxu
• Huang, Caiyun
• Wang, Wenhui
• Wang, Zijie
• Shi, Chenyu
• Yin, Xindi
• Sun, Linlin
• Gao, Youjun
• Wang, Fenglai

Titel

Effects of Diet Supplemented with Excess Pyrroloquinoline Quinone Disodium on Growth Performance, Blood Parameters and Redox Status in Weaned Pigs

Ist Teil von

• Animals (Basel), 2021-02, Vol.11 (2), p.359

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• The research was implemented to assess the safety of feeding excess of pyrroloquinoline quinone disodium (PQQ·Na ) to 108 Duroc × Landrace × Large White weaned pigs (BW = 8.38 ± 0.47 kg). Pigs were weaned at 28 d and randomly distributed to one of three diets with six replicates and six pigs per replicate (three males and three females). Pigs in the control group were fed a corn-soybean meal-based diet (without growth promoter) while the two experimental diets were supplied with 7.5 and 75.0 mg/kg PQQ·Na , respectively. Average daily gain (ADG), average daily feed intake (ADFI), feed conversion (F:G), diarrhea incidence, hematology, serum biochemistry, organ index and general health were determined. Diets supplementation with 7.5 mg/kg PQQ·Na in weaned pigs could increase ADG during the entire experimental period ( < 0.05). And there was a tendency to decrease F:G ( = 0.063). The F:G of weaned pigs fed 7.5 and 75.0 mg/kg PQQ·Na supplemented diets was decreased by 9.83% and 8.67%, respectively, compared to the control group. Moreover, pigs had reduced diarrhea incidence ( < 0.01) when supplemented with PQQ·Na . No differences were observed between pigs supplemented with 0.0, 7.5 and 75.0 mg/kg PQQ·Na diets on hematological and serum biochemical parameters as well as histological assessment of heart, liver, spleen, lung and kidney. At day 14, pigs had increased activity of glutathione peroxidase (GSH-Px) ( < 0.05), catalase (CAT) ( < 0.05) and total antioxidant capacity (T-AOC) ( < 0.05), and the serum concentration of malondialdehyde (MDA) was decreased ( < 0.01) with PQQ·Na supplementation. At day 28, pigs had increased activities of total superoxide dismutase (T-SOD) ( < 0.01), GSH-Px ( < 0.01), CAT ( < 0.05) and T-AOC ( < 0.01), and serum concentration of MDA was lower ( < 0.01) with PQQ·Na supplementation. In conclusion, PQQ·Na can improve weaned pigs growth performance and serum antioxidant status. Meanwhile high PQQ·Na inclusion of 75.0 mg/kg does not appear to result in harmful effects on growth performance of pigs.