Details

Autor(en) / Beteiligte

• Bozic, Ksenija
• Glisic, Branislava
• Radic-Tasic, Olga
• Knezevic, Bojana

Titel

Case report of Mikulicz's disease: A modern concept of an old entity

Ist Teil von

• Vojnosanitetski pregled, 2016-04, Vol.73 (4), p.393-396

Ort / Verlag

Serbia: Military Health Department, Ministry of Defance, Serbia

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Modern knowlegde defines Mikulicz´s disease as a part of immunoglobulin G4-related disease. The main feature is the presence of lymphoplasmacytic infiltrates, immunoglobulin G4 plasma cells positivity, distinctive storiform fibrosis and moderate eosinophilia. A 59-years old male presented with a mild keratoconjuctivitis sicca and enlarged lacrimal and salivary glands during the last two years. Althought clinical presentation of the patient was typical, earlier testing did not pinpoint Mikulicz ´s disease. By typical clinical presentation, elevated serum immunoglobulin G4 level and histopathological finding of lacrimal glands tissue we diagnosed Mikulicz´s disease successfully treated with corticosteroid therapy. We reported the first case of IgG4-related Mikulicz´s disease in Serbia. Our report highlights IgG4-related Mikulicz` s disease as an important differential diagnosis with Sjögren`s syndrome and lymphoproliferative disease in rheumatological practice.