Details

Autor(en) / Beteiligte

• Schmidt, Kazuko E
• Höving, Anna L
• Nowak, Katja
• An Mey, Nike
• Kiani Zahrani, Sina
• Nemeita, Britta
• Riedel, Lena
• Majewski, Agnes
• Kaltschmidt, Barbara
• Knabbe, Cornelius
• Kaltschmidt, Christian

Titel

Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells

Ist Teil von

• International journal of molecular sciences, 2024-04, Vol.25 (7), p.3593

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Cardiovascular diseases (CVDs) are often linked to ageing and are the major cause of death worldwide. The declined proliferation of adult stem cells in the heart often impedes its regenerative potential. Thus, an investigation of the proliferative potential of adult human cardiac stem cells (hCSCs) might be of great interest for improving cell-based treatments of cardiovascular diseases. The application of human blood serum was already shown to enhance hCSC proliferation and reduce senescence. Here, the underlying signalling pathways of serum-mediated hCSC proliferation were studied. We are the first to demonstrate the involvement of the transcription factor NF-κB in the serum-mediated proliferative response of hCSCs by utilizing the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC). RNA-Sequencing (RNA-Seq) revealed , , and as potential targets of NF-κB that are involved in serum-induced hCSC proliferation.