Details

Autor(en) / Beteiligte

• Cecchini, Diego M.
• Cañizal, Ana M.
• Rojas, Haroldo
• Arechavala, Alicia
• Negroni, Ricardo
• Bouzas, María B.
• Benetucci, Jorge A.

Titel

Kinetics of HIV-1 in Cerebrospinal Fluid and Plasma in Cryptococcal Meningitis

Ist Teil von

• Infectious disease reports, 2012-04, Vol.4 (2), p.e30-e30

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2012

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy- free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal therapy. HIV-1 CSF concentrations were significantly lower in both S2 and S3 with respect to S1. Plasma concentrations remained stable. HIV-1 concentrations were higher in plasma than CSF in all cases. Patients who survived the episode of CM (but not those who died) showed a decrease in CSF viral load, what suggests different viral kinetics of HIV-1 in the CSF according to the clinical course of this opportunistic disease.