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Probing Transcriptional Crosstalk between Cryptochromes and Iron-sulfur Cluster Assembly 1 ( MagR ) in the Magnetoresponse of a Migratory Insect
Ist Teil von
International journal of molecular sciences, 2023-07, Vol.24 (13), p.11101
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2023
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Many organisms can sense and respond to magnetic fields (MFs), with migratory species in particular utilizing geomagnetic field information for long-distance migration. Cryptochrome proteins (Crys) along with a highly conserved Iron-sulfur cluster assembly protein (i.e., MagR) have garnered significant attention for their involvement in magnetoresponse (including magnetoreception). However, in vivo investigations of potential transcriptional crosstalk between
and
genes have been limited. The brown planthopper,
, is a major migratory pest insect and an emerging model for studying MF intensity-related magnetoresponse. Here, we explored in vivo transcriptional crosstalk between
(
and
) and
in
. The expression of
and
were found to be sensitive to MF intensity changes as small as several micro-teslas. Knocking down
expression led to a significant downregulation of
but not
. The knockdown of either
or
individually did not significantly affect
expression. However, their double knockdown resulted in significant upregulation of
. Our findings clearly indicate transcriptional crosstalk between
and
known to be involved in magnetoresponse. This work advances the understanding of magnetoresponse signaling and represents a key initial step towards elucidating the functional consequences of these novel in vivo interactions.