Details

Autor(en) / Beteiligte

• Wu, Xingxuan
• Li, Zheng
• Wang, Zhao-Qi
• Xu, Xingzhi

Titel

The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM

Ist Teil von

• Frontiers in neuroscience, 2023-08, Vol.17, p.1242448-1242448

Ort / Verlag

Lausanne: Frontiers Research Foundation

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size that results in numerous developmental problems, including intellectual disability, motor and speech delays, and seizures. Hitherto, over 30 MCPH causing genes ( MCPHs ) have been identified. Among these MCPHs , MCPH5 , which encodes abnormal spindle-like microcephaly-associated protein (ASPM), is the most frequently mutated gene. ASPM regulates mitotic events, cell proliferation, replication stress response, DNA repair, and tumorigenesis. Moreover, using a data mining approach, we have confirmed that high levels of expression of ASPM correlate with poor prognosis in several types of tumors. Here, we summarize the neurological and non-neurological functions of ASPM and provide insight into its implications for the diagnosis and treatment of MCPH and cancer.