Details

Autor(en) / Beteiligte

• Soto, Felipe
• Torre-Sada, Luis F
• Mott, Frank E
• Kim, Sang T
• Nurieva, Roza
• Shannon, Vickie R
• Faiz, Saadia A
• Casal, Roberto F
• Altan, Mehmet
• Lin, Julie
• Sheshadri, Ajay

Titel

Sarcoidosis and Airway Disease After Immune Checkpoint Inhibitor Therapy: Case Study and Review of the Literature

Ist Teil von

• Journal of Immunotherapy and Precision Oncology, 2023-05, Vol.6 (2), p.111-116

Ort / Verlag

United States: Innovative Healthcare Institute

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Pulmonary toxicity from immune checkpoint inhibitor therapy is typically a severe and potentially fatal complication, but these observations are driven by the most common toxicity, pneumonitis. Rarer pulmonary immune related adverse events, like airway disease and sarcoidosis, may have a more benign course. In this case report, we present a patient in whom therapy with the PD-1 inhibitor pembrolizumab resulted in severe eosinophilic asthma and sarcoidosis. This is the first case showing that anti-IL-5 inhibition may be safe in patients who develop eosinophilic asthma after ICI therapy. We further show that sarcoidosis does not necessarily require treatment cessation. This case highlights relevant nuances when clinicians face pulmonary toxicities other than pneumonitis.