Details

Autor(en) / Beteiligte

• Lau, Kit-Man
• Yue, Grace Gar-Lee
• Chan, Yuk-Yu
• Kwok, Hin-Fai
• Gao, Si
• Wong, Chun-Wai
• Lau, Clara Bik-San

Titel

A review on the immunomodulatory activity of Acanthopanax senticosus and its active components

Ist Teil von

• Chinese medicine, 2019-07, Vol.14 (1), p.25-25, Article 25

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, the dried root and rhizome or stem of , is commonly known as Siberian ginseng or Ciwujia in Chinese. It is used all over the world as an adaptogen to enhance physical and mental performance for the sake of normal physiological functioning of human bodies under stress. In the theory of traditional Chinese medicine, Ciwujia can strengthen the spleen that is an essential organ for immunological response. Its traditional applications include inflammation, fatigue and cancer in which the immune-regulating function is always involved. In this article, the immunomodulatory activities of Ciwujia extracts, fractions and pure compounds were extensively reviewed first. Then, the possibility of upgrading the chemical markers to bioactive markers was explored. Finally, the potency of aqueous extract and ethanol extract in regulating cytokines production from human peripheral blood mononuclear cells was compared. We conclude that although various phytochemicals such as isofraxidin, syringin and eleutheroside E from Ciwujia have been shown to modulate immunological functions, the aqueous extract of Ciwujia as a whole possesses the most potent efficacy. Therefore, aqueous (rather than ethanol) extract of Ciwujia should be used in order to benefit from its immunomodulatory properties.