Details

Autor(en) / Beteiligte

• Tkachenko, Volodymyr V
• Muravyova, Elena A
• Desenko, Sergey M
• Shishkin, Oleg V
• Shishkina, Svetlana V
• Sysoiev, Dmytro O
• Müller, Thomas J J
• Chebanov, Valentin A

Titel

The unexpected influence of aryl substituents in N-aryl-3-oxobutanamides on the behavior of their multicomponent reactions with 5-amino-3-methylisoxazole and salicylaldehyde

Ist Teil von

• Beilstein journal of organic chemistry, 2014-12, Vol.10 (1), p.3019-3030

Ort / Verlag

Germany: Beilstein-Institut

Erscheinungsjahr

2014

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The switchable three-component reactions of 5-amino-3-methylisoxazole, salicylaldehyde and N-aryl-3-oxobutanamides under different conditions were studied and discussed. The unexpected influence of the aryl substituent in N-aryl-3-oxobutanamides on the behavior of the reaction was discovered. The key influence of ultrasonication and Lewis acid catalysts led to an established protocol to selectively obtain two or three types of heterocyclic scaffolds depending on the substituent in the N-aryl moiety.