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The unexpected influence of aryl substituents in N-aryl-3-oxobutanamides on the behavior of their multicomponent reactions with 5-amino-3-methylisoxazole and salicylaldehyde
Ist Teil von
Beilstein journal of organic chemistry, 2014-12, Vol.10 (1), p.3019-3030
Ort / Verlag
Germany: Beilstein-Institut
Erscheinungsjahr
2014
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
The switchable three-component reactions of 5-amino-3-methylisoxazole, salicylaldehyde and N-aryl-3-oxobutanamides under different conditions were studied and discussed. The unexpected influence of the aryl substituent in N-aryl-3-oxobutanamides on the behavior of the reaction was discovered. The key influence of ultrasonication and Lewis acid catalysts led to an established protocol to selectively obtain two or three types of heterocyclic scaffolds depending on the substituent in the N-aryl moiety.