Details

Autor(en) / Beteiligte

• Rowe, Suzanne J
• Pong-Wong, Ricardo
• Haley, Christopher S
• Knott, Sara A
• De Koning, Dirk-Jan

Titel

Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology

Ist Teil von

• Genetics selection evolution (Paris), 2009-01, Vol.41 (1), p.6-6, Article 6

Ort / Verlag

France: BioMed Central Ltd

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Variance component QTL methodology was used to analyse three candidate regions on chicken chromosomes 1, 4 and 5 for dominant and parent-of-origin QTL effects. Data were available for bodyweight and conformation score measured at 40 days from a two-generation commercial broiler dam line. One hundred dams were nested in 46 sires with phenotypes and genotypes on 2708 offspring. Linear models were constructed to simultaneously estimate fixed, polygenic and QTL effects. Different genetic models were compared using likelihood ratio test statistics derived from the comparison of full with reduced or null models. Empirical thresholds were derived by permutation analysis. Dominant QTL were found for bodyweight on chicken chromosome 4 and for bodyweight and conformation score on chicken chromosome 5. Suggestive evidence for a maternally expressed QTL for bodyweight and conformation score was found on chromosome 1 in a region corresponding to orthologous imprinted regions in the human and mouse. Initial results suggest that variance component analysis can be applied within commercial populations for the direct detection of segregating dominant and parent of origin effects.