Details

Autor(en) / Beteiligte

• Rouzaud, Claire
• Hay, Roderick
• Chosidow, Olivier
• Dupin, Nicolas
• Puel, Anne
• Lortholary, Olivier
• Lanternier, Fanny

Titel

Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review

Ist Teil von

• Journal of fungi (Basel), 2015-12, Vol.2 (1), p.4

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2015

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Dermatophytes are keratinophilic fungi responsible for benign and common forms of infection worldwide. However, they can lead to rare and severe diseases in immunocompromised patients. Severe forms include extensive and/or invasive dermatophytosis, , deep dermatophytosis and Majocchi's granuloma. They are reported in immunocompromised hosts with primary (autosomal recessive CARD9 deficiency) or acquired (solid organ transplantation, autoimmune diseases requiring immunosuppressive treatments, HIV infection) immunodeficiencies. The clinical manifestations of the infection are not specific. Lymph node and organ involvement may also occur. Diagnosis requires both mycological and histological findings. There is no consensus on treatment. Systemic antifungal agents such as terbinafine and azoles (itraconazole or posaconazole) are effective. However, long-term outcome and treatment management depend on the site and extent of the infection and the nature of the underlying immunodeficiency.